Lung Tissue Remodeling

The Eickelberg laboratory investigates lung tissue remodeling using molecular and cellular mechanisms, leading to pathological remodeling of lung structure. Abnormal remodeling is key to various chronic lung diseases, e.g. lung fibrosis, chronic obstructive lung disease (COPD), or bronchiolitis obliterans. State of the art genomic, biochemical, and cell biological methods, as well as mouse models, are used to elucidate remodeling processes contributing to such diseases. In particular, we are interested in signaling processes influencing epithelial cell plasticity, epithelial-mesenchymal crosstalk and extracellular matrix dynamics. Furthermore, we explore biomarkers and molecular signatures of cells involved in disease onset or progression, and correlate these findings to human samples.