Projects

1. Proteasome expression and function in normal and diseased lung (Asthma, Fibrosis, COPD, aging lung)

2. Effect of cigarette smoke on proteasome function and antigen processing:

• Modification of proteasome and alteration of activity?

• Generation of altered antigens?

• Role of immunoproteasome?  

3. Proteasome as a therapeutic target for lung disease:
Inhalative Application of Proteasome Inhibitors for Therapeutic Use in Mouse Models of Lung Cancer and Pulmonary Fibrosis
(together with the groups of Otmar Schmid and Tobias Stöger, funded by m4)

4. Understanding the differential cellular effects of low- versus high-dose proteasome inhibition